Severe hypercalcaemia and acute renal failure in an infant with subcutaneous fat necrosis

İnce Becerir T., Altincik A., Özhan B., YÜKSEL S.

Paediatrics and International Child Health, vol.41, no.3, pp.221-225, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/20469047.2021.1883960
  • Journal Name: Paediatrics and International Child Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.221-225
  • Keywords: Acute renal failure, hypercalcaemia, pamidronate, subcutaneous fat necrosis
  • Çanakkale Onsekiz Mart University Affiliated: No


Subcutaneous fat necrosis (SFN) in the newborn is a form of panniculitis which presents with erythematous nodules and indurated plaques. Severe life-threatening hypercalcaemia can occur as a late complication. A 2-month-old girl presented with severe hypercalcaemia and acute renal injury as a complication of SFN. She was admitted to hospital with the chief complaint of failure to thrive. She had a history of therapeutic hypothermia. After successful treatment of the hypercalcaemia with bisphosphonates, the acute renal injury recovered spontaneously. In neonates with SFN, acute renal injury is a rare complication of hypercalcaemia. Timely prevention of the complications of hypercalcaemia in SFN is essential.