Aim: Recurrent pregnancy loss (RPL) affects 1% pregnancies and its etiology is multi-factorial. Hypercoagulability might result in recurrent abortions; anticoagulant therapy could potentially increase the live-birth rate in subsequent pregnancies in women with unexplained recurrent abortions. Mean platelet volume (MPV) and platelet distribution width (PDW), are a parameter of platelet functions and may be a marker for increased platelet aggregability. In this study we aimed to determine whether MPV, PDW and red cell distribution width (RDW) values differ between patients with RPL and in healthy participants. Material and Method: A total of 50 RPL patients and 49 age matched healthy women were enrolled into the study. For all subjects following tests were performed: Hemoglobin, hematocrit, white blood cells counts (WBC), MPV, PDW, platelet count, RDW and thyroid stimulating hormone (TSH). Results: Compared with healthy controls there were no statistically differences in MPV and PDW between (p > 0.05, respectively) in women with RPL. However, RDW was significantly lower in patients with RPL than in group with control (p = 0.023,). Discussion: It was first shown in the literature that patients with RPL have no significance MPV and PDW than control subjects. However RDW levels were found that it was significantly related to recurrent pregnancy loss.