Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric Ischemia/Reperfusion in a rat model

KABAY B., Teke Z., Aytekin F. Ö., YENISEY C., BIR F., Sacar M., ...More

WORLD JOURNAL OF SURGERY, vol.31, no.8, pp.1707-1715, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1007/s00268-007-9112-5
  • Journal Name: WORLD JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1707-1715
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion.