Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric Ischemia/Reperfusion in a rat model

KABAY B., Teke Z., Aytekin F. Ö., YENISEY C., BIR F., Sacar M., ...Daha Fazla

WORLD JOURNAL OF SURGERY, cilt.31, sa.8, ss.1707-1715, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00268-007-9112-5
  • Dergi Adı: WORLD JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1707-1715
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion.