Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric Ischemia/Reperfusion in a rat model


KABAY B., Teke Z., Aytekin F. Ö. , YENISEY C., BIR F., Sacar M. , ...Daha Fazla

WORLD JOURNAL OF SURGERY, cilt.31, ss.1707-1715, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00268-007-9112-5
  • Dergi Adı: WORLD JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.1707-1715

Özet

Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion.