Controlled release from a nanocarrier entrapped within a microcarrier

Rojas E. C., Sahiner N., Lawson L., John V. T., Papadopoulos K. D.

JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol.301, no.2, pp.617-623, 2006 (SCI-Expanded) identifier identifier identifier identifier


This study illustrates the entrapment of the dye molecule fluorescein sodium salt (FSS) by hydrogel nanoparticles, which are in turn confined inside a water-in-oil-in-water double-emulsion globule, and its subsequent release by the action of the competing agent hydrochloric acid (HCI). Thus, a "double carrier" concept is being introduced in which a nanoscale delivery vehicle is being transported by a microscale delivery vehicle in order to simultaneously take advantage of both systems. This may facilitate storage and handling while protecting the active substance and improving its action upon application. (c) 2006 Elsevier Inc. All rights reserved.