Investigation of the Relationship Between Frailty and HALP and PNI Scores in Older Adults YAŞLI YETİŞKİNLERDE KIRILGANLIK İLE HALP VE PNI SKORLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Journal of Kirikkale University Faculty of Medicine, cilt.28, sa.2, ss.244-250, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.24938/kutfd.1849293
- Dergi Adı: Journal of Kirikkale University Faculty of Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.244-250
- Anahtar Kelimeler: Frailty, HALP score, PNI score
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to investigate the relationship between frailty and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a biomarker reflecting nutritional and inflammatory status, and the prognostic nutritional index (PNI), an indicator of nutritional and immunological status, in older adults. Material and Methods: A total of 205 participants aged 65 years and older were included in the study. Frailty was assessed using the clinical frailty scale, the FRAIL scale evaluating fatigue, resistance, ambulation, illnesses, and loss of weight, and the Edmonton Frail Scale. HALP and PNI scores were calculated for all participants and analyzed statistically. Results: According to all frailty scales, HALP and PNI scores were significantly lower in frail individuals (p<0.05 for all comparisons). Both HALP and PNI scores showed significant negative correlations with all frailty scales. In multivariable logistic regression analysis, only the PNI score was independently associated with frailty (Exp(B) = 0.906; 95% CI: 0.84–0.96; p=0.003). Conclusion: This study demonstrates that HALP and PNI scores are significantly associated with frailty in older adults, indicating that biochemical markers may play a complementary role in frailty assessment.