Electrocatalytic Oxidation of Acyclovir on Poly(p-Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode

CAN S., YILMAZ S., SAĞLIKOĞLU G., Sadikoglu M., Menek N.

ELECTROANALYSIS, cilt.27, sa.10, ss.2431-2438, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/elan.201500102
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2431-2438
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Acyclovir is an antiviral effective drug active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The polymer film-modified electrode was used to electrochemically detect acyclovir. Polymer film showed excellent electrocatalytic activity for the oxidation of acyclovir. The anodic peak potential value of the acyclovir at the poly(p-ABSA) modified glassy carbon electrode was 950mV obtained by DPV. A linear calibration curve for DPV analysis was constructed in the acyclovir concentration range 2x10(-7)-9x10(-6)molL(-1). Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 5.57x10(-8) and 1.85x10(-7)molL(-1) respectively. The proposed method exhibits good recovery and reproducibility.