Alterations of circulating endothelial cells after apheresis in patients with sickle cell disease: A potential clue for restoration of pathophysiology

Boga C., Kozanoglu I., Ozdogu H., Sozer O., Sezgin N., BAKAR C.

TRANSFUSION AND APHERESIS SCIENCE, cilt.43, sa.3, ss.273-279, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.transci.2010.09.015
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.273-279
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objectives: The potential influence of automated red cell exchange (ARCE) on endothelial activation is not well established. This study was intended to assess whether ARCE influences circulating endothelial cells (CECs) in patients with sickle cell disease. Background: Automated red cell exchange (ARCE) has been used to protect the patient from complications of sickle cell disease. However, the expected benefits vary in different patients. CECs reflect endothelial activation. We hypothesize that suppression of endothelial activation may be an important mechanism of ARCE.