Effects of therapeutic dose of ivermectin on plasma nitric oxide and total antioxidant capacity in rabbits

Atakisi E., Atakisi O., Topcu B., UZUN M.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.13, no.6, pp.425-429, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 6
  • Publication Date: 2009
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.425-429
  • Keywords: Ivermectin, Nitric oxide, Total antioxidant capacity, Adenosine deaminase, Rabbit
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background: Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals.