The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas

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Terzi N., Yilmaz I., Oz A. B.

TURKISH JOURNAL OF PATHOLOGY, vol.38, no.2, pp.90-98, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5146/tjpath.2021.01555
  • Journal Name: TURKISH JOURNAL OF PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.90-98
  • Keywords: Diffuse glioma, Primary glioblastoma, TERT p, Promoter mutation, Survival, DIFFUSE GLIOMAS, IDH, SUBGROUPS, 1P/19Q, ATRX, OLIGODENDROGLIOMA, TELOMERES, MARKERS, SUBSET, IMPACT
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene were identified in addition to the IDH, 1p / 19q, and ATRX status.