The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas

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Terzi N., Yilmaz I., Oz A. B.

TURKISH JOURNAL OF PATHOLOGY, cilt.38, sa.2, ss.90-98, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5146/tjpath.2021.01555
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.90-98
  • Anahtar Kelimeler: Diffuse glioma, Primary glioblastoma, TERT p, Promoter mutation, Survival, DIFFUSE GLIOMAS, IDH, SUBGROUPS, 1P/19Q, ATRX, OLIGODENDROGLIOMA, TELOMERES, MARKERS, SUBSET, IMPACT
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene were identified in addition to the IDH, 1p / 19q, and ATRX status.