Effects of amniotic membrane transplantation and mitomycin C on wound healing in experimental glaucoma surgery


Demir T. , TURGUT B. , AKYOL N., OZERCAN I., ULAS F., CELIKER U.

OPHTHALMOLOGICA, cilt.216, ss.438-442, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 216 Konu: 6
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1159/000067550
  • Dergi Adı: OPHTHALMOLOGICA
  • Sayfa Sayıları: ss.438-442

Özet

Purpose: To evaluate the effects of mitomycin C and amniotic membrane transplantation on the modulation of wound healing after glaucoma filtration surgery. Methods: Trabeculectomy was performed in 3 groups of 10 rabbit eyes each. Sponges soaked in mitomycin C were applied to the first group, and amniotic membranes were transplanted around the scleral flap in the second group; the third group was the control. The arithmetic means of fibroblast and macrophage numbers per square centimetre were calculated. Results: The mean numbers of fibroblasts and macrophages were decreased significantly in the mitomycin C group, compared with the controls (p < 0.0001). Cell counts in the amniotic membrane group were also lower than the ones in the control group for fibroblasts and macrophages (p < 0.0001, p < 0.01, respectively). The difference between the two treatment groups was statistically significant for fibroblasts (p < 0.0001), but not significant for macrophages (p > 0.05). Conclusion: In spite of the fact that amniotic membrane transplantation is less effective than mitomycin C for depressing wound healing after trabeculectomy, it might be a safer alternative in selected cases when considering severe adverse effects of antimetabolites. Copyright (C) 2002 S. Karger AG, Basel.