Potent antibacterial activity of oligo-3-aminopyridine against Staphylococcus aureus and Enterococcus faecalis

Akgul C., Kaya I.

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, vol.41, pp.120-122, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41
  • Publication Date: 2004
  • Journal Name: INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.120-122
  • Keywords: antibacterial activity, S. aureus, E. faecalis, oligo-3-aminopyridine, BACTERIA, DESIGN
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Oligo-3-aminopyridine (OAP) was tested for its antibacterial activity against two gram positive (Staphylococcus aureus and Enterococcus faecalis) and two gram negative (Escherchia coli and Pseudomonas aeruginosa) bacterial strains. Antibacterial efficacy was measured by disk diffusion assay. Inhibition zones demonstrated that 50 mug OAP showed strong antibacterial activity against the gram-positive strains; the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were found to be 25 mug/ml and 50 mug/ml, respectively. The results indicate that OAP is a potent antibacterial agent against S. aureus and E. faecalis.