Phosphazene-based nanostructures modified with gold nanoparticles as drug and gene carrier materials with antibacterial and antifungal properties

Ozsoy F., Özay Ö.

International Journal of Polymeric Materials and Polymeric Biomaterials, vol.73, no.5, pp.383-394, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1080/00914037.2022.2163642
  • Journal Name: International Journal of Polymeric Materials and Polymeric Biomaterials
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.383-394
  • Keywords: Drug release, functional material, gold nanoparticle, phosphazene, RNA
  • Çanakkale Onsekiz Mart University Affiliated: Yes


© 2023 Taylor & Francis Group, LLC.In this study, monodisperse spherical particles were synthesized by using hexachlorocyclotriphosphazene (HCCP) and 1-(2-Aminoethyl) piperazine (AEP) by the polycondensation reaction. Then, the surfaces of the synthesized nanospheres were functionalized with gold nanoparticles. Phz-AEP nanospheres and phz-AEP@Au nanocomposite were characterized by various methods. Drug release studies for the synthesized phz-AEP and phz-AEP@Au nanospheres were performed using a ribonucleic acid (RNA) and sodium diclofenac (NaDc). As a result of the release studies, the drug release kinetics of the nanospheres were investigated. Additionally, the antibacterial and antifungal effects of the synthesized phz-AEP and phz-AEP@Au nanocomposite spheres were tested.