Phosphazene-based nanostructures modified with gold nanoparticles as drug and gene carrier materials with antibacterial and antifungal properties

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Ozsoy F., ÖZAY Ö.

International Journal of Polymeric Materials and Polymeric Biomaterials, 2023 (SCI-Expanded)

• Publication Type: Article / Article
• Publication Date: 2023
• Doi Number: 10.1080/00914037.2022.2163642
• Journal Name: International Journal of Polymeric Materials and Polymeric Biomaterials
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
• Keywords: Drug release, functional material, gold nanoparticle, phosphazene, RNA
• Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

© 2023 Taylor & Francis Group, LLC.In this study, monodisperse spherical particles were synthesized by using hexachlorocyclotriphosphazene (HCCP) and 1-(2-Aminoethyl) piperazine (AEP) by the polycondensation reaction. Then, the surfaces of the synthesized nanospheres were functionalized with gold nanoparticles. Phz-AEP nanospheres and phz-AEP@Au nanocomposite were characterized by various methods. Drug release studies for the synthesized phz-AEP and phz-AEP@Au nanospheres were performed using a ribonucleic acid (RNA) and sodium diclofenac (NaDc). As a result of the release studies, the drug release kinetics of the nanospheres were investigated. Additionally, the antibacterial and antifungal effects of the synthesized phz-AEP and phz-AEP@Au nanocomposite spheres were tested.