Phosphazene-based nanostructures modified with gold nanoparticles as drug and gene carrier materials with antibacterial and antifungal properties
International Journal of Polymeric Materials and Polymeric Biomaterials, cilt.73, sa.5, ss.383-394, 2024 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 5
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/00914037.2022.2163642
- Dergi Adı: International Journal of Polymeric Materials and Polymeric Biomaterials
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Sayfa Sayıları: ss.383-394
- Anahtar Kelimeler: Drug release, functional material, gold nanoparticle, phosphazene, RNA
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
© 2023 Taylor & Francis Group, LLC.In this study, monodisperse spherical particles were synthesized by using hexachlorocyclotriphosphazene (HCCP) and 1-(2-Aminoethyl) piperazine (AEP) by the polycondensation reaction. Then, the surfaces of the synthesized nanospheres were functionalized with gold nanoparticles. Phz-AEP nanospheres and phz-AEP@Au nanocomposite were characterized by various methods. Drug release studies for the synthesized phz-AEP and phz-AEP@Au nanospheres were performed using a ribonucleic acid (RNA) and sodium diclofenac (NaDc). As a result of the release studies, the drug release kinetics of the nanospheres were investigated. Additionally, the antibacterial and antifungal effects of the synthesized phz-AEP and phz-AEP@Au nanocomposite spheres were tested.