Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia/reperfusion injury on healing of colonic anastomoses in rats


Teke Z., Aytekin F. Ö. , KABAY B., YENISEY C., AYDIN C., TEKIN K., ...More

WORLD JOURNAL OF SURGERY, vol.31, no.9, pp.1835-1842, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 9
  • Publication Date: 2007
  • Doi Number: 10.1007/s00268-007-9106-3
  • Title of Journal : WORLD JOURNAL OF SURGERY
  • Page Numbers: pp.1835-1842

Abstract

Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In recent animal studies, a delaying effect of remote organ I/R injury on the healing of colonic anastomoses has been demonstrated. In this study we investigated whether PDTC prevents harmful systemic effects of superior mesenteric I/R on left colonic anastomosis in rats.