Synthesis, structural aspects, and antimicrobial activity investigation of novel macrocyclic amide-containing compounds


Aghatabay N. M. , Gunduz S., Bas A., Turkyilmaz M., Karabulut H. R. F. , Dulger B.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol.48, no.6, pp.936-942, 2012 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1007/s10593-012-1080-5
  • Journal Name: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.936-942

Abstract

Macrocyclic 1(6),7(6)-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 1(6),8(6)-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10,13-tetraoxocyclotetradecaphane, 1(6),9(6)-dimethyl-1,9(2,4)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 1(6),10(6)-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3,8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, H-1, C-13 NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure-activity relationships are also discussed.