Synthesis, structural aspects, and antimicrobial activity investigation of novel macrocyclic amide-containing compounds

Aghatabay N. M. , Gunduz S., Bas A., Turkyilmaz M., Karabulut H. R. F. , Dulger B.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, cilt.48, sa.6, ss.936-942, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 48 Konu: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10593-012-1080-5
  • Dergi Adı: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Sayfa Sayıları: ss.936-942

Özet

Macrocyclic 1(6),7(6)-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 1(6),8(6)-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10,13-tetraoxocyclotetradecaphane, 1(6),9(6)-dimethyl-1,9(2,4)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 1(6),10(6)-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3,8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, H-1, C-13 NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure-activity relationships are also discussed.