Synthesis, structural aspects, and antimicrobial activity investigation of novel macrocyclic amide-containing compounds


Aghatabay N. M., Gunduz S., Bas A., Turkyilmaz M., Karabulut H. R. F., Dulger B.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, cilt.48, sa.6, ss.936-942, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10593-012-1080-5
  • Dergi Adı: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.936-942
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Macrocyclic 1(6),7(6)-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 1(6),8(6)-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10,13-tetraoxocyclotetradecaphane, 1(6),9(6)-dimethyl-1,9(2,4)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 1(6),10(6)-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3,8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, H-1, C-13 NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure-activity relationships are also discussed.