Blood levels of cytokines in children with idiopathic partial and generalized epilepsy

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Sonmez F. M., Serin H. M., ALVER A., ALİYAZICIOĞLU R., CANSU A., Cane G., ...More

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.22, no.7, pp.517-521, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1016/j.seizure.2013.03.014
  • Journal Name: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.517-521
  • Keywords: ILs, TNF-alpha, Topiramate, Valproic acid, Epilepsy, Child, ANTIEPILEPTIC DRUGS, TNF-ALPHA, IMMUNOGLOBULIN LEVELS, STATUS EPILEPTICUS, PLASMA-LEVELS, SEIZURES, SYSTEM, INTERLEUKIN-6, IMMUNOREACTIVITY, INFLAMMATION
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Purpose: Antiepileptic drugs have been reported to reduce the levels of serum immunoglobulins and affect the production and levels of certain cytokines. We investigated the effects of valproic acid (VPA) and topiramate (TPM) on the blood levels of interleukin (IL)-alpha, IL-1 beta, IL-6, IL-10, and TNF-alpha in children with idiopathic generalized and partial epilepsy.