Evidence for an association between tumor necrosis factor-alpha levels and lithium response

Guloksuz, Sinan; Altinbas, KÜRŞAT; ÇETİN, Esin; Kenis, Gunter; Gazioglu, Sema; DENİZ, Günnur; Oral, E.; van Os, Jim

doi:10.1016/j.jad.2012.04.044

Evidence for an association between tumor necrosis factor-alpha levels and lithium response

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Guloksuz S., Altinbas K., ÇETİN E., Kenis G., Gazioglu S. B., DENİZ G., ...More

JOURNAL OF AFFECTIVE DISORDERS, vol.143, pp.148-152, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 143
Publication Date: 2012
Doi Number: 10.1016/j.jad.2012.04.044
Journal Name: JOURNAL OF AFFECTIVE DISORDERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Page Numbers: pp.148-152
Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background: The role of inflammation in bipolar disorder has recently emerged as a potential pathophysiological mechanism. Tumor necrosis factor-alpha (TNIF-alpha) modulation may represent a pathogenic molecular target and a biomarker for staging bipolar disorder. In this context, the possible association between lithium response and TNF-alpha level was examined.