Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischema/reperfusion injury in rats

Teke Z., KABAY B., Aytekin F. Ö., YENISEY C., DEMIRKAN N. C., Sacar M., ...Daha Fazla

AMERICAN JOURNAL OF SURGERY, cilt.194, sa.2, ss.255-262, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 194 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.amjsurg.2006.06.054
  • Dergi Adı: AMERICAN JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.255-262
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

Background: Pyrrolidine dithiocarbamate (PDTQ is a low-molecular-weight thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate harmful effects of ischemia/reperfusion (I/R) injury in many organs. In recent animal studies, destructive effects of reperfusion injury has been demonstrated. In this study, we aimed to investigate whether PDTC prevents harmful effects of superior mesenteric I/R injury in rats.