Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischema/reperfusion injury in rats


Teke Z., KABAY B., Aytekin F. Ö. , YENISEY C., DEMIRKAN N. C. , Sacar M. , ...Daha Fazla

AMERICAN JOURNAL OF SURGERY, cilt.194, ss.255-262, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 194 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.amjsurg.2006.06.054
  • Dergi Adı: AMERICAN JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.255-262

Özet

Background: Pyrrolidine dithiocarbamate (PDTQ is a low-molecular-weight thiol antioxidant and potent inhibitor of nuclear factor-kappa B (NF-kappa B) activation. It has been shown to attenuate harmful effects of ischemia/reperfusion (I/R) injury in many organs. In recent animal studies, destructive effects of reperfusion injury has been demonstrated. In this study, we aimed to investigate whether PDTC prevents harmful effects of superior mesenteric I/R injury in rats.