Crystal structure of an arthritogenic anticollagen immune complex

Dobritzsch D., Lindh I., Uysal H., Nandakumar K. S., Burkhardt H., Schneider G., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.63, sa.12, ss.3740-3748, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 12
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/art.30611
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3740-3748
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

Objective In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation.