Crystal structure of an arthritogenic anticollagen immune complex

Dobritzsch D., Lindh I., Uysal H., Nandakumar K. S., Burkhardt H., Schneider G., ...More

ARTHRITIS AND RHEUMATISM, vol.63, no.12, pp.3740-3748, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1002/art.30611
  • Journal Name: ARTHRITIS AND RHEUMATISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3740-3748
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Objective In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation.