Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/ml


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Kaygisiz O., Ugurlu O., KOŞAN T. M. , Inal G., Oeztuerk B., Cetinkaya M.

PROSTATE CANCER AND PROSTATIC DISEASES, vol.9, no.3, pp.235-238, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1038/sj.pcan.4500885
  • Title of Journal : PROSTATE CANCER AND PROSTATIC DISEASES
  • Page Numbers: pp.235-238
  • Keywords: prostate inflammation, prostate-specific antigen, antibacterial therapy, prostate biopsy, CATEGORY-IV PROSTATITIS, SERUM PSA, ANTIGEN, MEN, HYPERPLASIA, PREVALENCE, BACTERIAL, CANCER, VOLUME

Abstract

We investigated the effect of prostatic inflammation on prostate-specific antigen (PSA) and per cent-free PSA levels changing after antibacterial therapy. We evaluated 48 patients whose PSA levels were between 4 and 10 ng/ml, without any suspicious findings on digital rectal examination, with no infection findings in urine analysis. Prostatic inflammation was assessed with prostatic massage. All the patients were given antibiotic therapy for 3 weeks. Patients were re-evaluated 3 weeks after antibacterial therapy with PSA (free/total) and urinalysis. Ten core biopsies were taken with transrectal ultrasound. No differences were found in terms of age, pre- and post-treatment PSA, and PSA varying between patients with and without inflammation in the prostatic massage. In 18 patients, PSA decreased below 4 ng/ml. Prostate cancer was found in 10.8% of the patients with PSA between 4 and 10 ng/ml and none of the patients with PSA values below 4 ng/ml. We suggest an antibiotic therapy for 3 weeks without regarding inflammation findings when PSA is in the gray zone, for biopsy decision.