Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates


POLAT ÇAKIR S. , Beksultanova N., DOĞAN Ö.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.193, ss.858-864, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 193 Konu: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/10426507.2018.1513521
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Sayfa Sayıları: ss.858-864

Özet

A series of unactivated racemic and chiral aziridine-2-phosphonates were synthesized by modified Gabriel-Cromwell reaction. Ring opening reaction of the synthesized phosphonates by gaseous HCl provided access to a wide range of biologically interesting novel beta-chloro-alpha-aminophosphonates. All reactions toward each of the above-mentioned products can be conducted regioselectively in high yields.