Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties


SILAN C., AKÇALI A., Otkun M. T. , Ozbey N., Butun S., ÖZAY Ö., ...More

COLLOIDS AND SURFACES B-BIOINTERFACES, vol.89, pp.248-253, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89
  • Publication Date: 2012
  • Doi Number: 10.1016/j.colsurfb.2011.09.024
  • Journal Name: COLLOIDS AND SURFACES B-BIOINTERFACES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.248-253
  • Keywords: Polymeric particles, Microgel, Nanogel, Antibacterial materials, Drug delivery systems, ANTIMICROBIAL PROPERTIES, POLYMERIC NANOPARTICLES, DUAL-ACTION, SILVER, COMPOSITES, POLY(4-VINYLPYRIDINE), NANOCOMPOSITES, MULTILAYER, LAYER

Abstract

Poly(acrylonitrile) (p(AN))-based materials such poly(acrylonitrile-co-(3-acrylamidopropyl)-trimethylammonium chloride (p(AN-co-APTMACl)), poly(acrylonitrile-co-4-viniyl pyridine) (p(AN-co-4-VP)) and poly(acrylonitrile-co-N-isopropylacrylamide) (p(AN-co-NIPAM)) core–shell nanoparticles were prepared. The core materials, AN, in p(AN-co-4-VP) nanoparticles, were amidoximated and the shell materials, 4-VP, were quaternized to generate p(AN-co-4-VP)+ and p(AN-co-4-VP)++, single and double positively charged core–shell nanoparticles, respectively. Furthermore, interpenetrating microgels-hydrogel (IPN) polymeric networks were prepared by mixing double quaternized p(AN-co-4-VP)++ core–shell particles with acrylamide (AAm) and 2-hydroxyethylmethacrylate (HEMA) before polymerization. A model drug, fluorescein sodium salt (FSS) was used in absorption/release studies from these IPNs. Moreover, the prepared and chemically modified particles were tested against Staphylococcus aureus ATCC6538, Pseduomonas aeruginosa ATCC9027, Bacillus subtilis ATCC6633, and Escherichia coli ATCC8739, and found that some of these particles had antibacterial properties against tested bacteria.

Poly(acrylonitrile) (p(AN))-based materials such poly(acrylonitrile-co-(3-acrylamidopropyl)-trimethylammonium chloride (p(AN-co-APTMACl)), poly(acrylonitrile-co-4-viniyl pyridine) (p(AN-co-4-VP)) and poly(acrylonitrile-co-N-isopropylacrylamide) (p(AN-co-NIPAM)) core-shell nanoparticles were prepared. The core materials, AN, in p(AN-co-4-VP) nanoparticles, were amidoximated and the shell materials, 4-VP, were quaternized to generate p(AN-co-4-VP)(+) and p(AN-co-4-VP)(++), single and double positively charged core-shell nanoparticles, respectively. Furthermore, interpenetrating microgels-hydrogel (IPN) polymeric networks were prepared by mixing double quaternized p(AN-co-4-VP)(++) core-shell particles with acrylamide (AAm) and 2-hydroxyethylmethacrylate (HEMA) before polymerization. A model drug, fluorescein sodium salt (FSS) was used in absorption/release studies from these IPNs. Moreover, the prepared and chemically modified particles were tested against Staphylococcus aureus ATCC6538. Pseduomonas aeruginosa ATCC9027. Bacillus subtilis ATCC6633, and Escherichia coli ATCC8739, and found that some of these particles had antibacterial properties against tested bacteria. (C) 2011 Elsevier B.V. All rights reserved.