A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

ATAGÜN M. İ., Canbek O. A.

ALPHA PSYCHIATRY, vol.23, no.2, pp.47-56, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 23 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5152/alphapsychiatry.2021.21584
  • Journal Name: ALPHA PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.47-56
  • Keywords: Electroconvulsive therapy, oxidative stress, glutathione peroxidase, superoxide dismutase, BIPOLAR DISORDER, SUPEROXIDE-DISMUTASE, IMMUNE-SYSTEM, DEPRESSION, PARAMETERS, ASSOCIATION, DAMAGE, ECT, SCHIZOPHRENIA, ELECTROSHOCK
  • Çanakkale Onsekiz Mart University Affiliated: No


Objective: Brain's aerobic energy metabolism, abundance of the fatty acids and unsaturated lipids, generation of Reactive Oxygen Species (ROS) by hormones, physiological roles of transition metals (i.e., iron and copper), and free radicals in the nervous system may cause inclination to oxidative stress in psychiatric disorders. Electroconvulsive therapy (ECT) may cause oxidative stress by the electrical field or by the induced seizure. It was aimed to review the literature in terms of the influence of ECT on levels of oxidant and antioxidant compounds.