Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary

Gol M., Saygili U., KOYUNCUOĞLU ÜLGÜN M., Uslu T.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.35, no.3, pp.429-433, 2009 (SCI-Expanded) identifier identifier identifier


Objective: High-dose methotrexate (MTX) is one of the most prescribed agents in many malignant diseases affecting girls and young women of reproductive ages. This animal study directly measures the primordial follicle loss following exposure to high-dose MTX.