Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary

Gol, Mert; Saygili, Ugur; KOYUNCUOĞLU ÜLGÜN, MERAL; Uslu, Turhan

doi:10.1111/j.1447-0756.2008.00945.x

Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary

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Gol M., Saygili U., KOYUNCUOĞLU ÜLGÜN M., Uslu T.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.35, no.3, pp.429-433, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 35 Issue: 3
Publication Date: 2009
Doi Number: 10.1111/j.1447-0756.2008.00945.x
Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.429-433
Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective: High-dose methotrexate (MTX) is one of the most prescribed agents in many malignant diseases affecting girls and young women of reproductive ages. This animal study directly measures the primordial follicle loss following exposure to high-dose MTX.