Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary


Gol M., Saygili U., KOYUNCUOĞLU ÜLGÜN M., Uslu T.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.35, no.3, pp.429-433, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1111/j.1447-0756.2008.00945.x
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Page Numbers: pp.429-433

Abstract

Objective: High-dose methotrexate (MTX) is one of the most prescribed agents in many malignant diseases affecting girls and young women of reproductive ages. This animal study directly measures the primordial follicle loss following exposure to high-dose MTX.