Development of a medication adherence scale for familial Mediterranean fever (MASIF) in a cohort of Turkish children

Yesilkaya S., Acikel C., Fidanci B. E., Polat A., Sozeri B., Ayaz N. A., ...More

Clinical and Experimental Rheumatology, vol.33, pp.156-162, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33
  • Publication Date: 2015
  • Journal Name: Clinical and Experimental Rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.156-162
  • Keywords: Adherence, Colchicine, Familial Mediterranean fever, Scale
  • Çanakkale Onsekiz Mart University Affiliated: No


Objective. To develop and assess the validity and reliability of an adherence scale concerning medical treatment in paediatric FMF patients. Methods. The Medication Adherence Scale in FMF Patients (MASIF) is a 18-item questionnaire that evaluates adherence to medication in four domains. Validation of the instrument was accomplished in paediatric FMF patients (aged 2-18 years) under medication at least for 6 months. The first step was to build up the scale through qualitative approach (with interviews using semi-structured questions). Validation analyses included assessment of feasibility, face and content validity; construct validity, internal consistency and test-retest reliability. Results. One hundred and fifty patients with FMF were enrolled in the study. The mean age of the patients was 11.11±4.02 years and 48.7% of them were male. The MASIF was found to be feasible and valid for both face and content. It correlated with the Morisky Medication Adherence Scale as a gold standard thereby demonstrating good construct validity (r=0.515, p < 0.001). Assessment of content validity identified four subscales. The internal consistency, Cronbach's alpha was 0.728. There was a positive and significant correlation between test and retest scores (r=0.843; p < 0.001). Also, a significant correlation between parents' and children's reports (r=0.781, p < 0.001). Conclusion. Based on these results, the use of this scale to assess and follow up the adherence to treatment in paediatric FMF patients under medical treatment is recommended.