Microwave assisted synthesis of Jeffamine cored PAMAM dendrimers


Erturk A. S. , TÜLÜ M., BOZDOĞAN A. E. , Parali T.

EUROPEAN POLYMER JOURNAL, vol.52, pp.218-226, 2014 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52
  • Publication Date: 2014
  • Doi Number: 10.1016/j.eurpolymj.2013.12.018
  • Journal Name: EUROPEAN POLYMER JOURNAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.218-226

Abstract

This study reports the use of a new microwave assisted amidation method for the synthesis of Jeffamine cored poly (amidoamine) (PAMAM) dendrimers up to fourth generations. Reaction proceeding is monitored by attenuated total reflectance (ATR) without final purification. It was found that current method decreases the aminolysis time, and minimizes the excessive use of reagents and solvents. Synthesized dendrimers were purified by liquid-phase polymer-based retention (LPR) technique and characterized by 1H-NMR, 13C-NMR, EA, GPC and UV–VIS spectroscopy.

This study reports the use of a new microwave assisted amidation method for the synthesis of Jeffamine cored poly (amidoamine) (PAMAM) dendrimers up to fourth generations. Reaction proceeding is monitored by attenuated total reflectance (ATR) without final purification. It was found that current method decreases the aminolysis time, and minimizes the excessive use of reagents and solvents. Synthesized dendrimers were purified by liquid-phase polymer-based retention (LPR) technique and characterized by H-1-NMR, C-13-NMR, EA, GPC and UV-VIS spectroscopy. (C) 2014 Elsevier Ltd. All rights reserved.