Electroanalytical determination of metronidazole in tablet dosage form


YILMAZ S., BALTAOGLU E., SAĞLIKOĞLU G., YAĞMUR S., Polat K., Sadikoglu M.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, vol.78, no.2, pp.295-302, 2013 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.2298/jsc120111069y
  • Journal Name: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.295-302

Abstract

In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH 4.01) using an UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and a sharp cathodic peak were observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3 x10(-6)-9x10(-5) mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 1.42x10(-7) and 4.76x10(-7) mol L-1 respectively.