Electroanalytical determination of metronidazole in tablet dosage form


YILMAZ S., BALTAOGLU E., SAĞLIKOĞLU G. , YAĞMUR S. , Polat K., Sadikoglu M.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, cilt.78, ss.295-302, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 78 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2298/jsc120111069y
  • Dergi Adı: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Sayfa Sayıları: ss.295-302

Özet

In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH 4.01) using an UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and a sharp cathodic peak were observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3 x10(-6)-9x10(-5) mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 1.42x10(-7) and 4.76x10(-7) mol L-1 respectively.