Electroanalytical determination of metronidazole in tablet dosage form
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, cilt.78, sa.2, ss.295-302, 2013 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.2298/jsc120111069y
- Dergi Adı: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.295-302
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH 4.01) using an UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and a sharp cathodic peak were observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3 x10(-6)-9x10(-5) mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 1.42x10(-7) and 4.76x10(-7) mol L-1 respectively.