The increasing cultural diversity around the globe requires nurses to be able to provide care to patients belonging to many different cultures. Nurses should be able to maintain a holistic approach toward caring for both patients and healthy individuals from different cultures so as not to ignore individual needs arising from cultural differences. To provide proper care according to cultural needs, a nurse necessarily requires a certain level of cultural competence. In this context, nurses are expected to enhance their cultural awareness and sensitivity to develop cultural competence, knowledge, and skills. This review aims to help fill the gap that exists in this area. It will also contribute to raising awareness among nurses about the importance of cultural competence by offering several new approaches to and suggestions for improving their caregiving skills in a culturally diverse world.