Electrochemical Investigation of Isoniazid on Poly (p-Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, cilt.10, sa.5, ss.4428-4438, 2015 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 5
- Basım Tarihi: 2015
- Dergi Adı: INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4428-4438
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Isoniazid is a tuberculostatic agent effective active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The electrochemical properties of isoniazid on modified electrode were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The polymer film-modified electrode was used to electrochemically detect isoniazid. The polymer film had excellent electrocatalytic activity for the oxidation of isoniazid. A linear calibration curve for DPV analysis was constructed in the isoniazid concentration range 2x10(-5) - 1x10(-4) mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.05x10(-6) and 1.01x10(-5) mol L-1 respectively. Isoniazid was determined in tablet dosage form. The proposed method exhibits good recovery and reproducibility. The mechanisms of electropolymerization were also suggested.