Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney

ALAN C., Kocoglu H., Altintas R., Alici B., ERSAY A. R.

ARCHIVES OF MEDICAL SCIENCE, vol.7, no.2, pp.211-216, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.5114/aoms.2011.22069
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.211-216
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Introduction: Transforming growth factor-beta 1 (TGF-beta 1) has a crucial role in collagen synthesis and fibrosis. TGF-beta 1 can be antagonized and/or reduced by the action of certain agents. We propose to identify the role of decorin in treatment of tubular and interstitial fibrosis and in the inhibition of TGF-beta 1 in an acute ischaemic kidney.