Nickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones


Gülten Ş.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.54, pp.1252-1260, 2017 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2017
  • Doi Number: 10.1002/jhet.2700
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1252-1260

Abstract

An efficient protocol is reported for the one-pot three-component Bignelli synthesis of a series of 3,4-dihydropyrimidine-2(1H)-ones and thiones in good yields (66-90%) from the aldehydes (4-benzyloxybenzaldehyde, 5-bromovanilin, 4-formyl-1-cyclohexene, and trans-cinnamaldehyde), -keto esters (ethyl acetoacetate, allyl acetoacetate, and t-butyl acetoacetate), and urea/thiourea in ethanol, using nickel chloride hexahydrate as a catalyst.