Introduction: There are many reports about the prognostic significance of the pathologic features of radical retropubic prostatectomy specimens in patients with localized prostate cancer. In our study we evaluated the relation between the preoperative free/total prostate specific antigen ratio (f/t PSA) and pathologic features of radical retropubic prostatectomy specimens. Materials and Methods: We retrospectively evaluated the data of 109 radical retropubic prostatectomy patients. Patients were divided into 3 groups according to their PSA levels (<10, 10-15, >15 ng/dl) and f/t PSA ratio (<0.10, 0.10-0.20, >0.20). We investigated the distribution of the patients to the groups according to pathologic features of radical retropubic prostatectomy specimens such as surgical margin positivity (SMP), extracapsular extension (ECE), seminal vesicle involvement (SVI), perineural invasion and pathologic stage. Results: Mean patient age was 61.6±5.9 years, mean PSA level was 10.6±6.7 ng/ml and mean f/t PSA ratio was 0.16±0.13. There was not any statistically significant difference between the PSA groups regarding the pathologic features of radical retropubic prostatectomy specimens (p>0.05). Pathological stage, SMP, ECE and SVI were higher in f/t PSA ratio <0.10 (p<0.05). Conclusion: We think that preoperative f/t PSA ratio could be a useful determinant for estimating the prognosis of radical retropubic prostatectomy patients according to pathological features of surgical specimens. Further studies with larger number of patients are needed to confirm these results.