CCR2 Polymorphism in Chronic Renal Failure Patients Requiring Long-Term Hemodialysis

Sezgin I., Koksal B., Bagci G., Kurtulgan H. K., ÖZDEMİR Ö.

INTERNAL MEDICINE, vol.50, no.21, pp.2457-2461, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 21
  • Publication Date: 2011
  • Doi Number: 10.2169/internalmedicine.50.5119
  • Journal Name: INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2457-2461
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective A number of chemokines and chemokine receptors are produced by intrinsic renal cells as well as by infiltrating cells during renal inflammation. The CCR2 chemokine receptor mediates leukocyte chemoattraction in the initiation and amplification phase of renal inflammation. The polymorphism, CCR2-V64I, changes valine 64 of CCR2 to isoleucine. We aimed to determine the frequency of CCR2-V64I polymorphism in patients with chronic renal failure requiring long-term hemodialysis.