Two Neglected Biologic Risk Factors in Bone Grafting and Implantology: High Low-Density Lipoprotein Cholesterol and Low Serum Vitamin D
JOURNAL OF ORAL IMPLANTOLOGY, cilt.40, sa.1, ss.110-114, 2014 (SCI-Expanded)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 40 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.1563/aaid-joi-d-13-00062
- Dergi Adı: JOURNAL OF ORAL IMPLANTOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.110-114
- Anahtar Kelimeler: cholesterol, LDL cholesterol, vitamin D, failures, implants, bone grafts, infections, immune defense, osseointegration
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır
Özet
Following a failure of a bone graft or an implant placement, the hypothesis of a biological abnormality is rarely considered as a possible cause. A systematic search of peer-reviewed literature for dyslipidemia or vitamin D deficiency may explain this lack of consideration. Excess low-density lipoprotein cholesterol (dyslipidemia) is responsible for a slower bone metabolism or lower dental implant osseointegration. In addition, vitamin D is a key factor for linking innate and adaptive immunity. Both of these factors are compromised under the conditions of vitamin D deficiency. Therefore, vitamin D deficiency slows implant osseointegration and increases the risk of graft infection. Vitamin D is also involved in immune function and therefore allergic reactions.