Radiotherapy-related Tiredness in Patients with Glioblastoma Multiforme (GBM)

Tuna-Malak A., Diramali A.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.9, no.3, pp.497-499, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2008
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.497-499
  • Çanakkale Onsekiz Mart University Affiliated: Yes


Tiredness may be caused by the brain injury due to the tumor or the treatment in patients with glioblastoma multiforme (GBM). Some patients describe a sense of tiredness particularly after radiation or oral chemotherapy. To evaluate tiredness level of patients with GBM during preoperative, postoperative and radiotherapy we here eamined a sample of 38 patients. Data were collected over six months in a neurosurgery clinic. Patients assigned to Group I were given a booklet and information about radiotherapy, oral temozolomide and tiredness. Group II received only the booklet. The chi-squared test were used to determine differences in tiredness between Group I and Group II, with Spearman's correlation for post-radiotherapy results (3 and 6 months postoperative). In conclusion, the level of tiredness was assessed to be significantly better in Group I than in Group II. Levels of tiredness in patients with GBM were greatly affected by the radiotherapy and oral chemotherapy (temozolomide).