Asymmetric dimethyl arginine levels in testicular tissue and blood of rats with induced experimental varicocele


ALAN C. , Ertung Y. , ÜLKER ÇAKIR D. , Topaloglu N. , ERSAY A. R. , BAŞTÜRK G.

REVISTA INTERNACIONAL DE ANDROLOGIA, vol.12, no.4, pp.139-144, 2014 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Review
  • Volume: 12 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.androl.2014.04.007
  • Title of Journal : REVISTA INTERNACIONAL DE ANDROLOGIA
  • Page Numbers: pp.139-144

Abstract

Introduction: Varicocele is one of the reasons for testicular dysfunction and is frequently known to accompany infertility. The basic pathology of varicocele is the development of endothelial dysfunction. The most important factors in development of endothelial dysfunction are impaired endothelial-linked vasodilatation, increase in free oxygen radicals, reduced synthesis and release of nitric oxide (NO), abnormal vasoconstriction and increased levels of dimethyl arginine. Our aim was to identify and illustrate the relationship between asymmetric dimethyl arginine (ADMA) and NO levels in testicular tissue and plasma of rats with induced experimental varicocele.