Fresenius Environmental Bulletin, vol.30, pp.1134-1146, 2021 (Peer-Reviewed Journal)
No evidence has been found to determine
whether moss extract affects fibrotic, inflammatory,
apoptotic and tissue homeostasis for tissue regeneration on rat’s liver tissue. In our study, 1 ml of distilled water (Group I), and 50 mg/kg (Group II), 100
mg/kg (Group III), 300 mg/kg (Group IV), 500
mg/kg (Group V) for 30 days’ doses of moss and by
gavage of a total of 30 female rats in liver tissue due
to the increase in the dose of moss histopathology
was revealed. Also, immunohistochemical staining
was performed to determine the immunoreactivity of
transcription factor nuclear factor Kappa-B (NFκB), tumor necrosis factor (TNF-α), which regulates
inflammation and immune response, and TUNEL
(Terminal deoxynucleotidyl transferase dUTP nick
end labeling) for the assessment of the apoptotic process. The stained tissue samples were evaluated with
the image analysis system under the research microscope and One-way ANOVA, Tukey test, which is
one of the nonparametric tests, was used to determine the differences between the groups statistically
and the results were evaluated according to p≤0.05.
We found that liver damage increased due to the increased dose of moss species used in the experiment.
At the same time, antioxidant activity was increased,
and apoptosis was increased. Considering these results, it was concluded that algae extract would have
anticancer properties and could be used in the pharmaceutical industry.