Acta Oecologica Carpatica, no.XI.II, pp.91-98, 2018 (Peer-Reviewed Journal)
Rhamnus catharticus L., has an
antioxidant and antimicrobial activity
whereas the cytotoxic effect of the plant may
be responsible for the emergence of these
properties.
The aim of this study was to evaluate
the genotoxic and cytotoxic potential of the
water and methanolic extract obtained from
the Rhamnus catharticus leaf in peripheral
lymphocyte culture by micronucleus assay
for 24- and 48-hours treatment period. Three
doses of Rhamnus catharticus extract (1, 2,
4 mg/ml) were selected as treatment group;
Mitomycin C (MMC) as positive and water
is used as negative control.
We found that all extracts had greater
toxicity compared to the negative control
and MMC toxicity was higher than other
concentrations. This might be caused by the
various ingredients from the plant extract
that are obtained due to the polarity of
solvents.