Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus

ÇAKINA S., Aydin B., BEYAZIT F.

GYNECOLOGICAL ENDOCRINOLOGY, cilt.36, sa.11, ss.1006-1009, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/09513590.2020.1769062
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1006-1009
  • Anahtar Kelimeler: Oxidative stress, thiol, disulfide homeostasis, gestational diabetes mellitus
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.