Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus

ÇAKINA S., Aydin B., BEYAZIT F.

GYNECOLOGICAL ENDOCRINOLOGY, vol.36, no.11, pp.1006-1009, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.1080/09513590.2020.1769062
  • Journal Name: GYNECOLOGICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.1006-1009
  • Keywords: gestational diabetes mellitus, Oxidative stress, thiol/disulfide homeostasis
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.