Relationship between oxytocin receptor gene polymorphism and hypertension in Turkish population

REVISTA PORTUGUESA DE CARDIOLOGIA, vol.2022, no.2022, pp.1-6, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 2022 Issue: 2022
Publication Date: 2022
Doi Number: 10.1016/j.repc.2021.06.028
Journal Name: REVISTA PORTUGUESA DE CARDIOLOGIA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
Page Numbers: pp.1-6
Çanakkale Onsekiz Mart University Affiliated: Yes

Introduction and objectives: Known to play a key role in uterine contraction and milk ejec-

tion, the neuropeptide, oxytocin, has cardiovascular effects. To date, the known cardiovascular

effects of oxytocin are blood pressure lowering (caused by natriuresis and atrial natriuretic

peptide release), negative inotropic and chronotropic effect caused by parasympathetic neu-

romodulation, anti-stress effect and vasodilation mediated by activation of the nitric oxide

pathway. The clinical significance of the rs2268498 polymorphism in oxytocin receptors in these

effects is controversial. Based on the known genetic inheritance of hypertension, our research

aimed to determine whether the presence of the rs2268498 oxytocin receptor (OXTR) allele C

affects hypertension in our region.

Methods: This article is a case-control study conducted in the Turkish population. About 140

normotensive and 140 isolated hypertensive volunteers included in the research and genotyped

with real-time PCR hybridization method via melt curve analysis.

Results: Oxytocin receptor rs2268498 polymorphism was assessed in terms of the risk of hyper-

tension and hypertensive individuals were compared to the control group. OXTR rs2268498

polymorphism was not found to be a significant risk factor for dominant, recessive and addi-

tive modeled hypertension (ORdominant: 0.966, 95% CI: 0.57-1.61, p: 0.9; ORrecessive: 1, 95% CI:

0.58-1.71, p: 1.0 and ORoverall: 0.98, chi2=0.01).

Conclusion: We concluded that rs2268498 single nucleotide polymorphism is not a risk factor

for hypertension in our region.

open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-

nc-nd/4.0/).

∗ Corresponding author.

E-mail address: mervemeliha@comu.edu.tr (M.M. Cicekliyurt).

https://doi.org/10.1016/j.repc.2021.06.028

BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Please cite this article as: M.M. Cicekliyurt and B. Dermenci, Relationship between oxytocin receptor gene polymorphism

and hypertension in Turkish population, Revista Portuguesa de Cardiologia, https://doi.org/10.1016/j.repc.2021.06.028