Action of aspirin on acetylcholine-stimulated tear secretion in rats

Kapicioglu Z., ÇAN G., Kalyoncu I.

Turkish Journal of Medical Sciences, vol.29, no.6, pp.623-625, 1999 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 1999
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.623-625
  • Keywords: Acetylcholine, Acetylsalicylic acid, Aspirin, Rat, Tear secretion
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were anesthetized intraperitoneally (ip) with urethane (1.2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60 mg/kg of ASA, group 3 received 50 mg/kg of Acetylcholine (Ach), and group 4 received 60 mg/kg of ASA and 30 min later 50 mg of Ach. While Ach alone significantly increased tear secretion. ASA reduced it when compared to saline (control) (p<0.0001 and p<0.01, respectively). Acetylsalicylic acid combined with Ach decreased tear secretion in comparison to Ach alone (p<0.001). In conclusion, ASA significantly inhibits Ach-stimulated tear secretion in rats.