Therapeutic effect of Tarantula cubensis extract on indomethacin induced gastric ulcers in rats

Makav M., Gelen V., GEDİKLİ S., Atila Uslu G., Uslu H., EROĞLU H. A.

THAI JOURNAL OF VETERINARY MEDICINE, vol.50, no.4, pp.559-566, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2020
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, Veterinary Science Database
  • Page Numbers: pp.559-566
  • Keywords: indomethacin-induced gastric ulcer, NF-kB, 8-OHdG, Rat, Tarantula Cubensis extract, NONSTEROIDAL ANTIINFLAMMATORY DRUG, HEME OXYGENASE-1
  • Çanakkale Onsekiz Mart University Affiliated: Yes


Non-steroid anti-inflammatory drugs (NSAIDs) have widely been used in patients but side-effects associated with NSAID are also common. Tarantula cubensis extract (TCE) is an antiphlogistic, demarcative, homeopathic and necrotizing drug with wound healing effects in farm animals. However, the therapeutic effects of TCE on gastric ulcers has not been investigated. The aim of this study was to investigate the gastroprotective effects of TCE against indomethacin-induced gastric injury in rats.