Electroanalytical Investigation of Paracetamol on Glassy Carbon Electrode by Voltammetry


ENGIN C., YILMAZ S. , SAĞLIKOĞLU G. , YAĞMUR S. , Sadikoglu M.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, vol.10, no.2, pp.1916-1926, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2015
  • Title of Journal : INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
  • Page Numbers: pp.1916-1926

Abstract

An electroanalytical method was developed for the direct quantitative determination of paracetamol (or acetaminophen) in tablet dosage forms based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on glassy carbon electrode (GCE) using a variety of voltammetric techniques. The electrochemical measurements were carried out on GCE in various buffer solutions in the pH range from 0.51 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the anodic peak current and peak potential was investigated. Acetate buffer (pH 4.51) was selected for analytical purposes. Scan rate studies were also completed. The diffusion controlled nature of the peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 4x10(-6) mol/L to 1x10(-4) mol/L. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.69x10(-7) mol/L and 1.23x10(-6) mol/L respectively. Validation of applied voltammetric techniques was checked with recovery studies.